Induction of chaperone mediated autophagy11/20/2023 BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria. Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria. Possible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality control. Mitophagy in hepatocytes: types, initiators and role in adaptive ethanol metabolism. Variants of mitochondrial autophagy: types 1 and 2 mitophagy and micromitophagy (type 3). Uth1 is a mitochondrial inner membrane protein dispensable for post-log-phase and rapamycin-induced mitophagy. Uth1p is involved in the autophagic degradation of mitochondria. Selective and non-selective autophagic degradation of mitochondria in yeast. Post-translational modifications of key machinery in the control of mitophagy. Mitophagy and quality control mechanisms in mitochondrial maintenance. Mitochondrial dynamics and mitochondrial quality control. Mitochondrial quality control and cellular proteostasis: two sides of the same coin. The origin and diversification of mitochondria. Cleaning house: selective autophagy of organelles. A diversity of selective autophagy receptors determines the specificity of the autophagy pathway. Machinery, regulation and pathophysiological implications of autophagosome maturation. At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy. ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery. Microautophagy in the yeast Saccharomyces cerevisiae. Three distinct types of microautophagy based on membrane dynamics and molecular machineries. Quantitative correlation between proteolysis and macro- and microautophagy in mouse hepatocytes during starvation and refeeding. Regulation of microautophagy and basal protein turnover in rat liver. A morphometric analysis with special reference to macro- and microautophagy. Quantitative changes in the lysosomal vacuolar system of rat hepatocytes during short-term starvation. J., Vreeling-Sindelarova, H., Schellens, J. Effects of pH, temperature, and proteolytic inhibitors. Degradation of short and long lived proteins in isolated rat liver lysosomes. Effects of pH, ATP, and inhibitors of proteolysis. Uptake–microautophagy–and degradation of exogenous proteins by isolated rat liver lysosomes. Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation. Suggestion of a microautophagic pathway of proteolysis. Uptake and degradation of proteins by isolated rat liver lysosomes. Microautophagy in mammalian cells: revisiting a 40-year-old conundrum. Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis. The coming of age of chaperone-mediated autophagy. A brief history of autophagy from cell biology to physiology and disease. Historical landmarks of autophagy research. A unified nomenclature for yeast autophagy-related genes. Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine. Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization. Autophagy revisited: a conversation with Christian de Duve. Future research into microautophagy will provide opportunities to develop novel interventional strategies for autophagy- and lysosome-related diseases. We also discuss the upstream regulatory mechanisms, the crosstalk between macroautophagy and microautophagy, and the functional implications of microautophagy in diseases such as cancer and neurodegenerative disorders in humans. Here we review this form of autophagy, focusing on selective forms of microautophagy. In recent years, there has been a growth in research on microautophagy, first in yeast and then in mammalian cells. The molecular mechanisms and biological functions of macroautophagy and chaperone-mediated autophagy have been extensively studied, but microautophagy has received much less attention. At present, the prevailing categories of autophagy in mammalian cells are macroautophagy, microautophagy and chaperone-mediated autophagy. Different forms of autophagy have been described on the basis of the nature of the cargoes and the means used to deliver them to lysosomes. ‘Autophagy’ refers to an evolutionarily conserved process through which cellular contents, such as damaged organelles and protein aggregates, are delivered to lysosomes for degradation.
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